![]() ![]() ![]() Another grand challenge, systems biology, seeks to form connections between all of the various classes of biomolecules in both space and time towards the comprehensive diagnosis of disease states ( 11), and MS is at the forefront of integrated omics approaches that will help realize this vision ( 12, 13, 14). ![]() To address this formidable challenge, researchers are turning to high-throughput screening using MS-based assays which are capable of screening up to 100,000 compounds a day from combinatorial small molecule libraries ( 18, 19).ĭrug discovery initiatives are aimed at finding the proverbial needles in haystacks in a molecular landscape of over 10 60 possible chemical structures ( 15, 16), which is a haystack containing a novemdecillion straws of hay, or about 40 orders-of-magnitude greater than the number of grains of sand on Earth ( 17). Genomics, which is driven by massively-paralleled DNA sequencers ( 20), is currently feeling the burden of big data, with a projected 2–40 million terabytes of genomic data being generated in the next ten years, representing anywhere from 100 million to 2 billion complete human genomes sequenced. ![]()
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